Therapies Available in Puhua

Radiofrequency Ablation

By using Ultrasound and CT technology, we are able to directly insert heat generating needles into the core of the cancer site. The area is then heated and once it exceeds60℃, a systematic breakdown of proteins in the cancer cells will occur degenerating to the point that they become harmless.

Cryosurgical Ablation (CSA)

Using imaging guided techniques (Ultrasound, CT or MRI), cryo-probes are inserted into tumors to lower the temperature of the targeted area -160℃ or lower. Later the temperature is raised between 20 to 40℃. This process is repeated two or three times, resulting in complete ablation of the tumor.

CSA has the following advantages:
• It is applicable to both small and large tumors. It can be used for ablation of single or multiple tumors.
• Cryosurgical ablation will not cause damage to large blood vessels and trachea, so it can be used to treat tumors near those areas.
• It is a painless operation, and it helps reduces pain caused by cancer.
• The whole process of cryosurgical ablation can be monitored through imaging techniques such as ultrasound, CT or MRI.
• After cancerous cells are destroyed by CSA, dead cancerous cells will release antigens which will stimulate the immune system to eradicate any remaining cancerous cells and reduce re-occurrence of cancer.
Cancer Microvascular Intervention (CMI)
By inserting a catheter into target arteries and injecting embolic material, chemotherapy agents or traditional Chinese medicine we are able to cause a loss of blood to the cancer cells which leads to ischemia necrosis of tumor tissue. By doing this we are able to starve out and kill the cancer.

NanoKnife Therapy
It is also known as Irreversible Electroporation (IRE). Its rationale goes like as follows: during the procedure, high electric-field and ultrashort pulses are given to destroy lipid bilayer structure of cancer cell membrane and form numerous irreversible nano-sized pores in the cell membrane. Cell membrane permeability will be changed to allow molecules of different sizes free access to cells, which will lead to cell death.

Nanoknife Therapy can be applied to treat tumors in solid organs such as pancreas, liver, lung, kidney and prostate, and is especially suitable for tumors adjacent to pancreas, hepatic hilar region, gallbladder, bile duct and ureters.

Photodynamic Therapy (PDT)
(sometimes called photo-chemotherapy), is a form of phototherapy using nontoxic light-sensitive compounds that are exposed to selective wavelengths of light, whereupon they become activated and toxic to targeted malignant and other targeted tissues. PDT has been proven to kill bacteria, fungi and viruses, and is popularly used in treating acne. It is used clinically to treat a wide range of medical conditions, including wet age-related macular degeneration (AMD) and malignant cancers, and is recognized as an effective and selective treatment strategy that is both minimally invasive and minimally toxic.

Immunotherapy (DC-CIK therapy)
CIK therapy (cytokine-induced killer cells): CIK cells are cytotoxic T-Cells that can seek and kill tumor cells. The number of CIK cells existing in body is very small, and not enough to fight against a cancer. In CIK therapy, CIK cells are isolated, amplified at least 1,000 times, and then re-infused back into the patient’s body.

Hyperthermia:
Experiments show that the cooling capacity of tumor cells is much lower than that of normal cells. When the temperature reaches 42.5 ℃ and lasted for more than 30 minutes, the tumor cells will rapidly heat up and cause injury, degeneration and necrosis. However, the healthy cells can avoid damage through good cooling mechanism. Thermotron-RF8 is Japan’s latest developed hyperthermia machine, which can accurately position the tumor and perform hyperthermia. While it reduces tumor volume and relieve pain, it can prevent the recurrence of cancer and enhance the effects of other therapies.

PD-1 Immunotherapy:
PD-1/PD-L1: PD-1 is one kind of active form T-cell surface receptor. The inner tumor microenvironment will induce the infiltrative T-cell high expressing PD-1 molecule, the tumor cell will high expressing the ligands of PD-1 (PD-L1 and PD-L2), which leading PD-1 pathway sustained activation in tumor microenvironment. After PD-L1 connecting with PD-1, T-cell function will be restrained, and unable to send out tumor attacking signals to immune system. PD-1/ PD-L1 inhibitor can interdict the connection of PD-1 and PD-L1, and interdict negative control signals to recover T-cell viability, and then improve the immune response. PD-1 and PD-L1 inhibitor have significant effect in a variety of cancer treatment.

Traditional Chinese Medicine (TCM)

TCM is a safe and effective supportive treatment option used in conjunction with other treatment
modalities. Many Chinese herbs have strong immune-enhancing effects, and can both enhance
the effects of chemotherapy, radiation therapy, surgery, and other modalities while reducing
toxicity and side-effects. Traditional Chinese herbs can be given orally, by IV infusion, or
injected to the tumor feeding vessels with the help of DSA (digital subtraction angiography)
guidance.

Multiple Discipline Medical Team